Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types
(2001) Journal of Immunology — Vol. 167, n° 7, p. 3545-3549 (2001)
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- Abstract
- IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far. Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2-8/IL-20R alpha and DIRS1/IL-20R beta (type I IL-20R). In addition, mda-7 and IL-20, but not IL-19, bind to another receptor complex, composed by IL-22R and DIRS1/ IL20R beta (type II IL-20R). In both cases, binding of the ligands results in STAT3 phosphorylation and activation of a minimal promoter including STAT-binding sites. Taken together, these results demonstrate that: 1) IL-20 induces STAT activation through IL-20R complexes of two types; 2) mda-7 and IL-20 redundantly signal through both complexes; and 3) IL-19 signals only through the type I IL-20R complex.
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Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S. V., & Renauld, J.-C. (2001). Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of Immunology, 167(7), 3545-3549. https://doi.org/10.4049/jimmunol.167.7.3545 (Original work published 2001)