Growth stimulation of mandibular condyles and femoral heads of newborn rats by IGF-I.
(2004) Archives of Oral Biology : a multidisciplinary journal of oral & craniofacial sciences — Vol. 49, n° 3, p. 165-175 (2004)
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- Primary and secondary cartilage differ in embryonic origin and are generally considered to have a different mode of growth. However, few experimental studies exist that directly compare the two types of cartilage and their growth regulation. The regulation of cartilage growth is a complex mechanism involving growth factors like insulin-like growth factor-I (IGF-I). The purpose of this study was to compare the growth of mandibular condyles of 4-day-old rats with that of femoral heads in vitro and to analyze the effects of IGF-I. Explants were cultured for up to 2 weeks with 0, 5, and 25 ng/ml IGF-1. Both, 5 and 25 ng/ml IGF-I significantly stimulated growth of the mandibular condyles while only 25 ng/ml IGF-I stimulated growth of the femoral heads. IGF-I increased glycosaminoglycan synthesis of both condylar and femoral cartilage. However, only the DNA synthesis of the mandibular condyles was significantly increased by IGF-I while that of the femoral heads was not affected. It is concluded that IGF-I stimulates growth of both secondary condylar cartilage and primary femoral cartilage. The mandibular condyle appears to be more sensitive to IGF-I than the femoral head, which may partly be due to the different developmental stage.
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Delatte, M., Von den Hoff, J. W., Maltha, J. C., & Kuijpers-Jagtman, A. M. (2004). Growth stimulation of mandibular condyles and femoral heads of newborn rats by IGF-I. Archives of Oral Biology : a multidisciplinary journal of oral & craniofacial sciences, 49(3), 165-175. https://doi.org/10.1016/j.archoralbio.2003.09.007 (Original work published 2004)