Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

Bueno, AB;Collado, I;de Dios, A;Dominguez, C;Herin, MF.;et.al.
(2005) Journal of Medicinal Chemistry — Vol. 48, n° 16, p. 5305-5320 (2005)

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Authors
  • Bueno, AB
    Author
  • Collado, I
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  • de Dios, A
    Author
  • Dominguez, C
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  • Herin, MF.
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Abstract
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (1), also known as LY354740, is a highly potent and selective agonist for group II metabotropic glutamate receptors (mGlu receptors 2 and 3) tested in clinical trials. It has been shown to block anxiety in the fear-potentiated startle model. Its relatively low bioavailability in different animal species drove the need for an effective prodrug form that would produce a therapeutic response at lower doses for the treatment of anxiety disorders. We have investigated the increase of intestinal absorption of this compound by targeting the human peptide transporter hPepT1 for active transport of di- and tripeptides derived from 1. We have found that oral administration of an N dipeptide derivative of 1 (12a) in rats shows up to an 8-fold increase in drug absorption and a 300-fold increase in potency in the fear-potentiated startle model in rats when compared with the parent drug 1.
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Bueno, A., Collado, I., de Dios, A., Dominguez, C., Martin, J., Martin, L., Martinez-Grau, M., Montero, C., Pedregal, C., Catlow, J., Coffey, D., Clay, M., Dantzig, A., Lindstrom, T., Monn, J., Jiang, H., Schoepp, D., Stratford, R., Tabas, L., et al. (2005). Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist. Journal of Medicinal Chemistry, 48(16), 5305-5320. https://doi.org/10.1021/jm050235r (Original work published 2005)