In vivo mechanisms of action of ulipristal acetate, a selective progesterone receptor modulator, in uterine fibroid volume reduction
(2018)
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- Uterine fibroids are the most common benign tumor in women of reproductive age. Ulipristal acetate (UPA) therapy permanently reduces the volume of fibroids in ~80% of cases. However, its in vivo mechanism of action remains unclear, and why some fibroids do not respond to treatment is not known. The present work aimed to identify the mechanism(s) by which UPA mediates its effects in fibroids, and the reasons for the lack of response in some cases by comparing biopsies from untreated or UPA-treated patients, taking into account the response profile. We have demonstrated that UPA in vivo causes inhibition of cell proliferation, cell death during the first few months of therapy, and very important remodeling of the extracellular matrix. The response to treatment depends on the stimulation of cell death and the action of matrix metalloproteinases which play key roles in the resorption of fibrosis
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Courtoy, G. E. (2018). In vivo mechanisms of action of ulipristal acetate, a selective progesterone receptor modulator, in uterine fibroid volume reduction. https://hdl.handle.net/2078.5/60750