Study of the underlying mechanism of the hypercoagulable state in acute leukaemia and impact of specific treatments on the thrombotic risk
(2015)
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- Patients with haematological malignancy have a 28-fold increase risk to develop venous thromboembolism (VTE). Among patients with acute myelogenous leukaemia, the incidence of VTE was 5,2%, and among patient with acute lymphoblastic leukaemia, the incidence of VTE was 4.5% in the first two year of disease. Despite the influence on mortality and morbidity, the mechanisms inducing a hypercoagulable state (thrombosis and DIC) are not fully understood to date. The primary role of extracellular vesicles (EVs) in the thrombosis physiopathology is one of the mechanisms recently suggested in solid tumour. However, this hypothesis has not been studied in acute leukaemia. The aim of this work is to study the function of EVs derived from leukemic cells in VTE and DIC associated with acute leukaemia. This study allowed : i) the development of several technics to study procoaguant EVs derived from cancer cells ii) a better understanding of hypercoagulable state induction mechanisms in acute leukaemia, iii) the validation of EVs as biomarker of the risk of VTE in acute leukaemia.
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Gheldof, D. (2015). Study of the underlying mechanism of the hypercoagulable state in acute leukaemia and impact of specific treatments on the thrombotic risk. https://hdl.handle.net/2078.5/187826