Alternative activation of mast cells by CD4+ T helper cells.
(2024) Journal of Leukocyte Biology — Vol. 116, n° 5, p. 1127-1141 (2024)
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- Authors
Espinosa, Eric 
- Abstract
- Effector CD4+ T (Teff) lymphocytes infiltrate sites of inflammation and orchestrate the immune response by instructing local leukocytes. Mast cells (MCs) are tissue sentinel cells strategically located near blood vessels and T cell-rich areas. MC/Teff cell interactions shape Teff cell responses, but in turn, Teff cell action on MCs is still poorly understood. Here, we analyzed the human MC/Teff cell interplay through both the application of RNA sequencing and functional assays. We showed that activated Teff cells induce a specific transcriptomic program in MCs including production of both inflammatory cytokines and chemokines, prostaglandin, and a FcεRI-dependent degranulation facilitation, thereby driving them toward an inflammatory phenotype. Moreover, Teff cells induce in MCs the capacity to interact with CD4+ T cells through a wide range of dedicated soluble and membrane ligands and to play the role of antigen-presenting cells.
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Citations
Leveque, E., Battut, L., Petitfils, C., Valitutti, S., Cenac, N., Dietrich, G., & Espinosa, E. (2024). Alternative activation of mast cells by CD4+ T helper cells. Journal of Leukocyte Biology, 116(5), 1127-1141. https://doi.org/10.1093/jleuko/qiae139 (Original work published 2024)