Effects of strychnopentamine on cells cultured in vitro.
(1991) Chemico-Biological Interactions — Vol. 80, n° 2, p. 203-216 (1991)
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- This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (less than 1 microgram/ml) after 72 h of treatment in the two lines. Incorporation of [3H]thymidine and [3H]leucine by B16 cells significantly decreases after only 1 h of treatment at 0.5 microgram/ml. SP induces the formation of dense lamellar bodies and vacuolization in the cytoplasm, intense blebbing at the cell surface and various cytological alterations leading to cell death.
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Quetin-Leclercq, J., De Pauw-Gillet, M.-C., Angenot, L., & Bassleer, R. (1991). Effects of strychnopentamine on cells cultured in vitro. Chemico-Biological Interactions, 80(2), 203-216. https://doi.org/10.1016/0009-2797(91)90025-3 (Original work published 1991)