Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality

Cani, Patrice;Van Hul, Matthias;Bachmann, Radu
(2023) Gut — Vol. 73, n° 1, p. 3-4 (2023)

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Abstract
Sepsis constitutes a global burden on medical care and accounts for nearly 20% of reported global mortality.1 The development of sepsis is complex, though the triggering of a disproportional systemic proinflammatory response is considered pivotal in driving organ dysfunction and subsequent mortality. As functional pattern recognition receptors, toll-like receptors (TLRs) play a predominant role in this context. Hence, approaches aimed at limiting their activation are considered valuable strategies for mitigating the organ damage and mortality occurring during the advancement of sepsis.
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Cani, P., Van Hul, M., & Bachmann, R. (2023). Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality. Gut, 73(1), 3-4. https://doi.org/10.1136/gutjnl-2023-331092 (Original work published 2023)