Poly(ortho Esters) As Bioerodible Matrices for the Controlled Delivery of Pyrimethamine in Chemoprophylaxis of Malaria

Vandamme, TF.;Heller, J.
(1995) Journal of Controlled Release — Vol. 36, n° 3, p. 209-213 (1995)

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  • Vandamme, TF.
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  • Heller, J.
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Abstract
Implants containing pyrimethamine were prepared from bioerodible poly(ortho esters). In vitro rate of drug release of physically entrapped pyrimethamine was examined as a function of the incorporated suberic acid. As found previously for other systems, increasing the concentration of suberic acid predictably increased rate of release of pyrimethamine. In vivo studies were carried out in rabbits to establish the pharmacokinetic profile and protection against Plasmodium berghei was carried out in a mouse model. Implants containing 21 wt% pyrimethamine and 5 wt% suberic acid provided protection for as long as three months.
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Vandamme, TF., & Heller, J. (1995). Poly(ortho Esters) As Bioerodible Matrices for the Controlled Delivery of Pyrimethamine in Chemoprophylaxis of Malaria. Journal of Controlled Release, 36(3), 209-213. https://doi.org/10.1016/0168-3659(95)00012-W (Original work published 1995)