The therapy of tuberculosis has undergone major changes in the past 10 years, short course regimens emerging as recommended standard treatment. Historically, guidelines for treating tuberculosis in children have been extrapolated from studies in adults. However childhood tuberculosis differ from adult tuberculosis in several ways that may greatly affect the treatment. These differences include: a) smaller bacterial population (less contagiosity, less secondary resistance, less yielding of culture); b) propensity for extrapulmonary disease; c) differences in pharmacokinetics of antitiberculosis drugs. The basic principles that underlie the treatment of pulmonary tuberculosis are briefly discussed as well as current options for therapy in children.
Lebecque, P. (1994). Traitement de la tuberculose pulmonaire chez l’enfant : ce qui a changé. Louvain médical, 113(2), 91-94. https://hdl.handle.net/2078.5/186684 (Original work published 1994)