In the advanced stage of prostate cancer, bone is consistently the first and, later on, the dominant extra-nodal metastatic site. Bone metastases account for most of prostate cancer's morbidity.
Butoescu, V. R., & Tombal, B. (2014). Practical guide to bone health in the spectrum of advanced prostate cancer. Canadian Journal of Urology, 21(2 Supp 1), 84-92. https://hdl.handle.net/2078.5/196548 (Original work published 2014)