Gammapathies monoclonales de signification indéterminée
(2013) Louvain médical — Vol. 132, n° 2, p. 51-62 (2013)
Files
2013-Vekemans-LouvainMédical.pdf
Restricted Access - Adobe PDF
- 489.34 KB
Details
- Authors
- Abstract
- (en) Monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of an intact monoclonal immunoglobulin in the serum (up to 30 g/l), in the absence of lytic bone lesions, anaemia, hypercalcaemia, and renal failure related to the underlying plasma cell disorder, with fewer than 10% monoclonal plasma cells in the bone marrow, This condition is considered to be a potential precursor to multiple myeloma or related lymphoproliferative disorders, The prevalence of MGUS is estimated at 3% in the general population over 70 years of age, but it is higher in Africans compared to Caucasians, The most common monoclonal protein is IgG, followed by IgM and IgA, IgM monoclonal proteins are associated with lymphoproliferative conditions, such as Waldenstrom's macroglobulinemia, non-Hodgkin lymphoma, or chronic lymphocytic leukemia, while IgG and IgA are commonly observed in multiple myeloma, Once detected, staging investigations are undertaken depending on the isotype, initial laboratory test results, and patient's age, The risk of progression to multiple myeloma or related disorders, which is estimated at approximately 1% per year, persists over time, justifying longterm follow-up, Risk scores predicting progression are based on the monocolonal protein levels, isotype, and kappa-lambda ratio, MGuS has been linked to a higher incidence of fractures, thromboembolic diseases, as well as neurological, renal, and infectious complications.
- Affiliations
Citations
Vekemans, M.-C., Caers, J., Doyen, C., & Michaux, L. (2013). Gammapathies monoclonales de signification indéterminée. Louvain médical, 132(2), 51-62. https://hdl.handle.net/2078.5/193448 (Original work published 2013)