Transcriptomic responses of alveolar macrophages under PSLT particle overload : influence of species and particle characteristics
(2025)
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- Abstract
- Chronic inhalation of poorly soluble low toxicity (PSLT) particles like titanium dioxide (e.g. P25) or carbon black (e.g. Printex 90) at high doses leading to lung overload, can induce chronic inflammation and lung cancer in rats. However, the relevance of these findings to humans and other PSLT particles remains debated. To address this, we examined gene expression profiles of rat and human alveolar macrophages exposed in vitro to P25 and Printex 90 particle overload. While rat cells were more responsive, both species showed a unique transcriptomic profile in response to P25 and Printex 90. An additional profile was identified in human cells exposed to Printex 90. We also examined rat macrophage responses to P25 and pigment grades TiO2 particles. Particles with higher specific surface areas (P25) had increased reactivity to overload. Our findings highlight the roles of species differences and physicochemical particle characteristics in modulating the responses to PSLT particle overload.
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Perez, L. (2025). Transcriptomic responses of alveolar macrophages under PSLT particle overload : influence of species and particle characteristics. https://hdl.handle.net/2078.5/243081