Antihypertensive mechanism of the dipeptide Val-Tyr in rat aorta
(2008) Invertebrate Neuropeptide Conference (INC 2007) — Location: Luang Prabang(Laos) (2007)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 439.24 KB
Details
- Authors
- Abstract
- Antihypertensive peptides received much interest over the last decade. These peptides are known to be angiotensin converting enzyme (ACE) inhibitors in vitro, but the actual antihypertensive mechanisms in vivo are still unclear. In this research, we used rat aortic rings in organ bath experiments to investigate five potential vascular antihypertensive mechanisms of the dipeptide Val-Tyr. Only one significant effect was observed, namely preincubation of the aorta with Val-Tyr led to a significant shift of the concentration-response curve evoked by angiotensin I (Ang I). Val-Tyr had no effect on the angiotensin 11 receptor or the alpha-adrenergic receptor. Furthermore, it did not interact with voltage-operated Ca2+, channels, or with nitric oxide production/availability. In conclusion, our results show that Val-Tyr specifically inhibits Ang I-evoked contraction through ACE inhibition and that four other main mechanisms of vascular tone regulation are not affected. (c) 2007 Elsevier Inc. All rights reserved.
- Affiliations
Citations
Vercruysse, L., Morel, N., Van Camp, J., Szust, J., & Smagghe, G. (2008). Antihypertensive mechanism of the dipeptide Val-Tyr in rat aorta. Peptides, 29(2), 261-267. https://doi.org/10.1016/j.peptides.2007.09.023 (Original work published 2008)