Polyclonal B lymphocyte activation induced by mouse hepatitis virus A59 infection
(1996) Journal of General Virology — Vol. 77, p. 1005-1009 (1996)
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- Authors
Coutelier, Jean-Paul 
- Abstract
- Mouse hepatitis viruses (MHV) diversely affect immune responses, depending on the viral strain and the mouse genetic background. Here, we studied the effect of MHV-A59 infection on B cell responses of 129/Sv and CBA mice. Our results indicate that in these strains, MHV-A59 induces spleen cell activation that leads to enlargement of the spleen without structural alteration. Infection triggers production by B lymphocytes of large amounts of immunoglobulin G2a, mostly without viral specificity. This polyclonal immunoglobulin production is dependent on the presence of functional T helper cells. This polyclonal B lymphocyte activation induced by MHV-A59 infection can have pathological implications, such as the enhancement of concomitant autoimmune reactions.
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Citations
Lardans, V., Godfraind, C., Vanderlogt, JTM., Heessen, FWA., Gonzalez, M., & Coutelier, J.-P. (1996). Polyclonal B lymphocyte activation induced by mouse hepatitis virus A59 infection. Journal of General Virology, 77, 1005-1009. https://doi.org/10.1099/0022-1317-77-5-1005 (Original work published 1996)