Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus.

Le-Thi-Phuong, Thao;Thirion, Gaëtan;Coutelier, Jean-Paul
(2007) Journal of General Virology —

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Authors
  • Le-Thi-Phuong, ThaoUCLouvain
    Author
  • Thirion, GaëtanUCLouvain
    Author
  • Coutelier, Jean-Paulorcid-logoUCLouvain
    Author
Abstract
Two distinct pathways of gamma interferon (IFN-gamma) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN-gamma production and requires the secretion of interleukin-12. This regulation of IFN-gamma production by type I interferons may help to control indirect pathogenesis induced by this cytokine.
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Le-Thi-Phuong, T., Thirion, G., & Coutelier, J.-P. (2007). Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus. Journal of General Virology. https://doi.org/10.1099/vir.0.83242-0