DNA transfer in the skin

Vandermeulen, Gaëlle;Daugimont, Liévin;Préat, Véronique
(2008) Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches — ISBN: [978-0-8493-7589-7], 537-555, published

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Authors
  • Vandermeulen, GaëlleUCLouvain
    Author
  • Daugimont, LiévinUCLouvain
    Author
  • Préat, VéroniqueUCLouvain
    Author
Abstract
The skin represents an attractive site for the delivery of nucleic acid-based drugs for the treatment of topical or systemic diseases and immunization. However, attempts at therapeutic cutaneous gene delivery have been hindered by several factors. Usually, except for viral vectors, gene expression is transient and typically disappears with one to two weeks due to the continuous renewal of the epidermis. Moreover, DNA penetration is limited by the barrier properties of the skin, rendering topical application rather inefficient.
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Vandermeulen, G., Daugimont, L., & Préat, V. (2008). DNA transfer in the skin. In Kenneth A. Walters (ed.), Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches (pp. 537-555). Informa Healthcare. https://doi.org/10.3109/9780849375903-34