Paracetamol overdose causing acute kidney injury without hepatotoxicity: a case report.
(2024) International Journal of Emergency Medicine — Vol. 17, n° 1, p. 81 [1-4] (2024)
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- Abstract
- BACKGROUND: Paracetamol is a widely used analgesic and antipyretic. Paracetamol-induced hepatotoxicity is well known, but nephrotoxicity without hepatotoxicity is rarely seen. CASE PRESENTATION: We present a case of acute kidney injury without hepatotoxicity in paracetamol overdose. A 15-year-old girl was admitted 48 h after she had taken 10 g of paracetamol. She was complaining of abdominal pain and vomiting. Her blood level of creatinine was 1.20 mg/dL on admission, with a peak at 3.67 mg/dL 3 days later. The liver blood tests and blood paracetamol level were negative. She did not receive N-acetyl cysteine and was treated with intravenous fluid (crystalloid). The ultrasonography of the kidneys was normal. Her renal function returned almost to baseline 7 days after admission. It was concluded that the diagnosis was an acute kidney injury caused by acute tubular necrosis due to paracetamol overdose. CONCLUSION: This case shows that nephrotoxicity can occur without hepatotoxicity in paracetamol overdose.
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Saad, M., & Flament, J. (2024). Paracetamol overdose causing acute kidney injury without hepatotoxicity: a case report. International Journal of Emergency Medicine, 17(1), 81 [1-4]. https://doi.org/10.1186/s12245-024-00662-w (Original work published 2024)