Using a new double-coil TMS method to study vulnerability markers in addictions
(2020)
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- Authors
- Supervisors
- Duqué , Julie
- Abstract
- The present thesis is articulated around three main axes. The first one focuses on assessing whether it is possible to obtain reliable motor-evoked potentials in both hands at once using a paired-pulse transcranial magnetic stimulation (TMS) method where the two primary motor cortices are stimulated with an inter-pulse interval as short as 1 ms (double-coil1ms TMS). The second axis assesses the function(s) of preparatory inhibition and more specifically its suggested role for behavioural inhibition. The third one investigates with double-coil1ms TMS whether preparatory inhibition is altered in two distinct populations, that is, in one likely to suffer from alcohol-use disorder (i.e., binge-drinkers) and in one suffering from gambling disorder. Our results are threefold. First, they infer that double-coil1ms is a reliable TMS method that can be used both at rest and in the context of a task. Second, they support and extend previous work on the presence and role of preparatory inhibition. Last, they suggest abnormal preparatory activity in binge-drinkers but not in patients suffering from gambling disorder.
- Affiliations
Citations
Grandjean, J. (2020). Using a new double-coil TMS method to study vulnerability markers in addictions. https://hdl.handle.net/2078.5/120212