Hepatic haemangioendothelioma: A proteiform disease.
(2020) Digestive and Liver Disease — Vol. 52, n° 9, p. 1039-1040 (2020)
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- (en) Hepatic haemangioendothelioma (HEHE) is a rare vascular tumor developed in a normal liver. HEHE is a combination of epithelioid and histiocytoid vascular endothelial cells surrounded by fibrotic stroma with a pathognomonic CAMTA1/WWTR1 fusion at the molecular level. Most patients present with a multinodular and bilobar liver disease (87%); moreover, extrahepatic spread at the time of diagnosis is frequent (36.6%). Most data about HEHE came from old series or large series of patients treated by liver transplantation (LT). [...]
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Gigante, E., Lai, Q., Lerut, J., & Nault, J.-C. (2020). Hepatic haemangioendothelioma: A proteiform disease. Digestive and Liver Disease, 52(9), 1039-1040. https://doi.org/10.1016/j.dld.2020.05.041 (Original work published 2020)