Efficiency of autologous stem cell collection: Comparison of threedifferent cell separators

Deneys, Véronique;Fabry, Annick;Vanhooydonk, Maryse;Sonet, Anne;Botson, Françoise;et.al.
(2017) Transfusion and Apheresis Science — Vol. 56, n° 1, p. 35-38 (2017)

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Abstract
tPeripheral blood progenitor cells (PBPC) infusion allows rapid haematological recovery after high dosechemotherapy. Efficient PBPC collection is therefore essential as rescue therapy for transplantation. Inorder to validate a new equipment (ComTec®, Fresenius Kabi), we compared the efficiency of three cellseparators for PBPC collection in patients with haematological malignant diseases. From June 2014 toDecember 2015, 83 PBPC were collected in 48 patients. Three aphaeresis machines were used: CobeSpectra®(Terumo BCT, 11), Amicus®(Fenwall, 30), and ComTec®(Fresenius Kabi, 42). The median col-lection efficiency was similar between the three separators. The evaluation of cell contamination in thefinal product revealed a lower red cell contamination with Spectra®and ComTec®, whereas the plateletcontamination was lower with Amicus®. The new equipment has been validated and can be further usedin routine, with a total running cost that turned out to be quite lower. Each separator has its own charac-teristics and advantages. Further study is needed to suggest that the choice of separator could be guidedfollowing the patient’s blood characteristics.
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Deneys, V., Fabry, A., Vanhooydonk, M., Sonet, A., André, M., Bourgeois, M., & Botson, F. (2017). Efficiency of autologous stem cell collection: Comparison of threedifferent cell separators. Transfusion and Apheresis Science, 56(1), 35-38. https://doi.org/10.1016/j.transci.2016.12.015 (Original work published 2017)