Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function.
(2011) Fertility and Sterility — Vol. 96, n° 6, p. 1407-1411 (2011)
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- Authors
- Abstract
- OBJECTIVE: To report the restoration of ovarian function in a woman with Turner syndrome by allografting ovarian cortex from her monozygotic twin. DESIGN: Case report. SETTING: Gynecology research unit in a university hospital. PATIENT(S): A 37-year-old woman with Turner syndrome who had suffered premature ovarian failure (POF) at the age of 15. INTERVENTION(S): In this woman, we performed ovarian cortex transplantation. The donor was her monozygotic twin who had not experienced POF and who had had two normal deliveries. MAIN OUTCOME MEASURE(S): Restoration of ovarian activity and pregnancy. RESULT(S): Restoration of ovarian function was achieved 3 months after transplantation. After 7 months of regular cycles, spontaneous pregnancy occurred. The patient delivered a healthy baby girl weighing 2,850 g at 38 weeks of gestation. CONCLUSION(S): Girls with Turner syndrome suffer accelerated loss of ovarian follicles and only 2%-5% experience spontaneous menses with the potential to achieve pregnancy without medical intervention. This manuscript reports the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant growth pattern and ovarian function.
- Affiliations
Hôpital de Parly II-Le Chesnay, france Gyn-Obst
Citations
Dolmans, M.-M., Squifflet, J.-L., Kerbrat, G., & Jadoul, P. (2011). Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function. Fertility and Sterility, 96(6), 1407-1411. https://doi.org/10.1016/j.fertnstert.2011.09.012 (Original work published 2011)