Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism?
(2019) Clinical Toxicology — Vol. 57, n° 7, p. 672-673 (2019)
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- Dear Editor, An 18-year-old woman was admitted six hours after the ingestion of a maximal estimated dose of 18,000mg of extend-release flecainide that was her chronic treatment for supraventricular tachycardia. On arrival, she had a Glasgow Coma Scale score 3 that progressed from 3 to 6/15. Arterial blood pressure was 96/79mm Hg, heart rhythm was 63/min, irregular. The electrocardiogram (ECG) revealed irregular rhythm with broad QRS complexes (220 ms). The initial laboratory investigation has revealed: arterial pH 7.21, bicarbonate 14 mmol/L, lactate 10.6 mmol/L, creatinine 1.4 mg/dL. The patient received 100 mmol of intravenous sodium bicarbonate and 1000 mL of fluids. [...]
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Hantson, P., Wuidart, C., & Haufroid, V. (2019). Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism? Clinical Toxicology, 57(7), 672-673. https://doi.org/10.1080/15563650.2018.1542703 (Original work published 2019)