The Ca2+ -ATPase SERCA3 influences membrane potential and the pattern of cytosolic [Ca2+]i oscillations in glucose-stimulated mouse beta-cells

Beauvois, Mélanie C;Rolland, Jean-François;Jonas, Jean-Christophe;Merezak, Charafa;Gilon, Patrick;et.al.
(2004) 40th EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Germany) Munich (5.September.2004)

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Authors
  • Beauvois, Mélanie C
    Author
  • Rolland, Jean-François
    Author
  • Jonas, Jean-Christopheorcid-logoUCLouvain
    Author
  • Merezak, CharafaUCLouvain
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  • Ravier, Magalie AUCLouvain
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  • Henquin, Jean-ClaudeUCLouvain
    Author
  • Gilon, Patrickorcid-logoUCLouvain
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Abstract
BACKGROUND AND AIMS: The low-affinity Ca2+-ATPase SERCA3 is highly expressed in p-cells. It mediates uptake of cytosolic Ca2+ by the endoplasmic reticulum during each period of Ca2+ influx from the extracellular medium, whereas the high-affinity SERCA2b controls basal [Ca'+t For unknown reasons, p-cells within mouse islets display variable patterns of [Ca2 +], oscillations during glucose (G) stimulation. These oscillations can be either regular and fast, or mixed with rapid oscillations superimposed on slow ones. We studied the role of the membrane potential (MP) and the possible intervention of SERCA3 in the generation of both types of [Ca2 +], oscillations. [...]
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Beauvois, M. C., Rolland, J.-F., Jonas, J.-C., Merezak, C., Ravier, M. A., Henquin, J.-C., & Gilon, P. (2004). The Ca2+ -ATPase SERCA3 influences membrane potential and the pattern of cytosolic [Ca2+]i oscillations in glucose-stimulated mouse beta-cells. Diabetologia : clinical and experimental diabetes and metabolism, 47(Suppl 1), A80. https://hdl.handle.net/2078.5/119050 (Original work published 2004)