Paternal Inheritance of Translocation Chromosomes in a T(x-21) Patient With X-linked Muscular-dystrophy

Kean, VM.;Macleod, HL.;Thompson, MW.;Ray, PN.;Worton, RG.;et.al.
(1986) Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics — Vol. 23, n° 6, p. 491-493 (1986)

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Authors
  • Kean, VM.
    Author
  • Macleod, HL.
    Author
  • Thompson, MW.
    Author
  • Ray, PN.
    Author
  • Dumoulin, ChristineUCLouvain
    Author
  • Worton, RG.
    Author
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Abstract
A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.
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Kean, VM., Macleod, HL., Thompson, MW., Ray, PN., Dumoulin, C., & Worton, RG. (1986). Paternal Inheritance of Translocation Chromosomes in a T(x-21) Patient With X-linked Muscular-dystrophy. Journal of Medical Genetics : an international peer-reviewed journal for health professionals and researchers in all areas of genetics, 23(6), 491-493. https://doi.org/10.1136/jmg.23.6.491 (Original work published 1986)