Longevity and cognitive resilience in a Colombian family carrying the APOE ε2 variant
(2026) Journal of Alzheimer’s Disease — Vol. 112, n° 1, p. 104-111 (2026)
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- Authors
Alejandro Guerrero 
Daniel Vásquez
- Abstract
- (en) APOE is the strongest genetic risk factor for late-onset Alzheimer's disease. Despite global efforts to promote resilience, delay cognitive decline, and slow aging, APOE ε2, one of the most robust resilience-associated variants, remains relatively underexplored in translational research. Exceptional longevity offers a window into cognitive trajectories. We present clinical, cognitive and neuroimaging data from five APOE ε2/ε3 siblings aged 94–105. Cognition ranged from normal to mild dementia. MRI showed less atrophy than expected for advanced age, and FDG-PET revealed preserved metabolism. Findings demonstrate APOE ε2-associated resilience in the oldest-old and offer insight into mechanisms of exceptional cognitive aging with potential translational relevance.
- Affiliations
Universidad de Antioquia Grupo de Neurociencias de Antioquia, Facultad de Medicina
Citations
Alejandro Guerrero, Nelson David Galvis-Garrido, Yamile Bocanegra, Daniel Vásquez, Juan Camilo Becerra, Yesica Zuluaga, Ana Baena, Victoria Zubiri, Diana Alzate, Laura Osorio, Liliana Hincapié, Lucia Madrigal, Gloria García, Claudia Guzmán, Feliza Restrepo, Mónica Vidal, Lusiana Martínez, Jairo E. Martínez, Malotaux, V., et al. (2026). Longevity and cognitive resilience in a Colombian family carrying the APOE ε2 variant. Journal of Alzheimer’s Disease, 112(1), 104-111. https://doi.org/10.1177/13872877261449392 (Original work published 2026)