Toxicokinetic Interaction between Quetiapine and Antiretroviral Therapy following Quetiapine Overdose.

Hantson, Philippe;Wallemacq, Pierre;Di Fazio, V.
(2010) Drug Metabolism Letters — Vol. 4, n° 1, p. 7-8 (2010)

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A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
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Hantson, P., Wallemacq, P., & Di Fazio, V. (2010). Toxicokinetic Interaction between Quetiapine and Antiretroviral Therapy following Quetiapine Overdose. Drug Metabolism Letters, 4(1), 7-8. https://doi.org/10.2174/187231210790980426 (Original work published 2010)