Distinct requirements for IL-6 in polyclonal and specific Ig production induced by microorganisms.
(2001) International Immunology — Vol. 13, n° 9, p. 1185-1192 (2001)
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- Authors
Coutelier, Jean-Paul 
- Abstract
- The role of IL-6 in Ig production induced in the mouse by lactate dehydrogenase-elevating virus (LDV), Toxoplasma gondii or lipopolysaccharide (LPS) was assessed. Following infection with LDV, a strong activator of B cells, an early and transient IL-6 production was observed, that originated predominantly from macrophages. Whereas LDV-induced B lymphocyte proliferation appeared independent of IL-6, mice deficient for this cytokine showed a marked reduction in their total T-dependent IgG2a production when compared to their normal counterparts. By contrast, specific responses directed against either LDV or non-viral antigens administered at the time of infection were not decreased in the absence of IL-6. Similarly, polyclonal, but not anti-parasite IgG2a production triggered by T. gondii infection was strongly dependent on the presence of IL-6. Finally, T-independent total IgG3 secretion triggered by LPS was also markedly reduced in IL-6-deficient mice. These results suggest that IL-6 plays a major role in T-dependent and T-independent polyclonal Ig production following B lymphocyte activation by viruses, and parasites, but not in specific antibody responses induced by the same microorganisms.
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Citations
Markine-Goriaynoff, D., Nguyen, T. D., Bigaignon, G., Van Snick, J., & Coutelier, J.-P. (2001). Distinct requirements for IL-6 in polyclonal and specific Ig production induced by microorganisms. International Immunology, 13(9), 1185-1192. https://doi.org/10.1093/intimm/13.9.1185 (Original work published 2001)