This review provides evidence that osteoarthritis (OA) or a major subset of OA is not only a disease of cartilage but also a disorder of subchondral bone. This review also discusses the potential efficacy of a bone and cartilage active agent, calcitonin, and discusses how calcitonin might be useful in the pharmaceutical treatment of OA.
Manicourt, D., Devogelaer, J.-P., Azria, M., & Silverman, S. (2005). Rationale for the potential use of calcitonin in osteoarthritis. Journal of Musculoskeletal Interactions, 5(3), 285-293. https://hdl.handle.net/2078.5/99242 (Original work published 2005)