CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.

Elens, Laure;Nieuweboer, Annemieke;Clarke, Stephen J;Charles, Kellie A;van Schaik, Ron H N;et.al.
(2013) Pharmacogenomics —

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  • Elens, LaureUCLouvain
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  • Nieuweboer, Annemieke
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  • Clarke, Stephen J
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  • Charles, Kellie A
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  • van Schaik, Ron H N
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Abstract
The CYP3A4*22 allele was recently reported to be associated with reduced CYP3A4 activity. We investigated the impact of this allele on the metabolism of the CYP3A-phenotyping probes, midazolam (MDZ) and erythromycin.
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Elens, L., Nieuweboer, A., Clarke, S. J., Charles, K. A., de Graan, A.-J., Haufroid, V., Mathijssen, R. H. J., & van Schaik, R. H. N. (2013). CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin. Pharmacogenomics. https://doi.org/10.2217/pgs.12.202