Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation
(2025) Journal of Neurophysiology — Vol. 134, n° 6, p. 1897-1911 (2025)
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- Previous studies have shown an association between interindividual variations in the frequency of a-band EEG oscillations suchas estimates of peak alpha frequency (PAF) and pain sensitivity. Whether differences in PAF also influence the susceptibility todevelop central sensitization (CS) is unknown. This study aimed to determine whether the PAF of vision- and sensorimotor-related alpha-band activity is associated with the magnitude and extent of secondary mechanical hyperalgesia induced by high-frequency stimulation (HFS) of the skin, a surrogate marker of CS. The EEG was recorded in 32 healthy participants at rest dur-ing eyes open and eyes closed conditions, and during bilateral finger movements. Then, HFS was applied to the right forearm.Pinprick sensitivity was assessed at both forearms, before and 40 min after HFS, to assess the magnitude and extent of HFS-induced secondary hyperalgesia. Two methods were used to isolate vision- and sensorimotor-related alpha-band activity basedon sensitivity to eye closure and movement: one based on an independent component analysis, the other on spectral subtrac-tion. PAF was characterized using a center-of-gravity approach and also using Gaussian fitting after removal of the aperiodicEEG component. Neither sensorimotor- nor vision-related PAF were significantly correlated with the magnitude or extent of HFS-induced secondary hyperalgesia. However, exploratory analyses revealed that participants with higher vision-related PAFshowed greater pinprick habituation at the nonsensitized forearm, indicating a possible link between PAF and perceptual habitu-ation. Interindividual variations of PAF at baseline were not significantly associated with the susceptibility to develop HFS-induced secondary hyperalgesia.
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Louisien Lebrun, Gloria Ricci, Arthur S. Courtin, Emanuel N. van den Broeke, Cédric Lenoir, & André Mouraux. (2025). Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation. Journal of Neurophysiology, 134(6), 1897-1911. https://doi.org/10.1152/jn.00278.2025 (Original work published 2025)