Phosphocholine May Allow for Listeriolysin-Mediated Escape of Phagocytized Listeria From Vacuolar Compartments Into the Host Cytosol While Protecting Against Overt Destruction of the Infected Cell.

Tulkens, Paul M.
(2020) The Journal of Infectious Diseases — Vol. 222, n° 9, p. 1425-1427 (2020)

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  • Tulkens, Paul M.orcid-logoUCLouvain
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Abstract
In this issue of the Journal of Infectious Diseases, La Pietra et al [1] discuss the role of phosphocholine, the product liberated from phosphatidyl choline by the phosphatidylcholine-specific phospholipase C (PC-PLC), as an inhibitor of listeriolysin O (LLO) activity. This investigation opens important avenues and potential developments in our understanding of how bacterial toxins disrupt the membranes of eukaryotic cells and thereby trigger lethal processes in the host. [...]
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Tulkens, P. M. (2020). Phosphocholine May Allow for Listeriolysin-Mediated Escape of Phagocytized Listeria From Vacuolar Compartments Into the Host Cytosol While Protecting Against Overt Destruction of the Infected Cell. The Journal of Infectious Diseases, 222(9), 1425-1427. https://doi.org/10.1093/infdis/jiaa023 (Original work published 2020)