Evidence and role for plasma membrane lipid domains in the spatial control of myoblast migration
(2024)
Files
PUBLICTHESIS-VANDERROOSTJuliette.pdf
Open Access - Adobe PDF
- 27.5 MB
Details
- Authors
- Supervisors
- Tyteca, Donatienne
- Abstract
- Myoblast migration is essential for muscle formation and renewal during myogenesis. However, the mechanisms governing myoblast migration have not been fully elucidated. This thesis tests the hypothesis that plasma membrane lipids can actively participate in the regulation of myoblast migration by forming areas of differential lipid composition and biophysical properties, i.e. lipid domains, and explores the underlying mechanism. We showed the presence of different types of lipid domains differentially enriched in sphingomyelin, cholesterol and GM1 ganglioside at the surface of myoblasts and their differential role for myoblast migration in association with the cytoskeleton, focal adhesions and the mechanosensitive cation channel Piezo1. We also revealed the differential implication of Piezo1 for myoblast migration depending on the migration context. Our study opens the way towards elucidating the role of lipid domains in cell migration in other pathophysiological contexts.
- Affiliations
Citations
Vanderroost, J. (2024). Evidence and role for plasma membrane lipid domains in the spatial control of myoblast migration. https://hdl.handle.net/2078.5/233824