Exploring Phage-Antibiotic Synergies for the Treatment of Biofilm-related Infectious Diseases
(2024)
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- Abstract
- For infectious diseases, not only the rapid emergence of bacterial resistance mechanisms towards routinely used antibiotics but also the formation of so-called biofilms, observed in an estimated 80% of all clinical infections, is resulting in the high rate of treatment failure observed in the clinics today. Over the last few years, bacteriophages (the viral predators of bacteria), have re-entered the spotlight as alternative or adjuvant therapeutic agents to antibiotics due to the ever-worsening antibiotic resistance crisis. Their abundance, ubiquity, co-evolutionary potential, and high bacterial specificity make them an attractive treatment approach for biofilm-related and pan-drug resistant, bacterial infections. In the present work, a large collection of bacteriophages targeting P. aeruginosa & S. aureus/epidermidis has been de novo isolated, purified and characterized from a wide variety of environmental sources. Subsequent phage-antibiotic synergy assays performed on both mono- and multispecies biofilm models delineated the high therapeutic potential of phage-antibiotic combinations in different medical settings (including Orthopedic and Cystic Fibrosis-related infections).
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Citations
De Soir, S. (2024). Exploring Phage-Antibiotic Synergies for the Treatment of Biofilm-related Infectious Diseases. https://hdl.handle.net/2078.5/243985