No association between Alport's syndrome and antithyroid antibodies.

Lambert, Michel;Pirson, Yves;De Nayer, Philippe;Van Ypersele de Strihou, Charles
(1992) Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association — Vol. 7, n° 11, p. 1082-1084 (1992)

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  • Lambert, MichelUCLouvain
    Author
  • Pirson, YvesUCLouvain
    Author
  • De Nayer, PhilippeUCLouvain
    Author
  • Van Ypersele de Strihou, CharlesUCLouvain
    Author
Abstract
The presence of circulating antithyroid antibodies in a small number of patients with Alport's syndrome has led some to suggest that the two abnormalities are associated. If confirmed, such an association could have important diagnostic as well as pathophysiological implications. Using sensitive methods, we assessed the prevalence of antithyroid antibodies in 40 patients with Alport's syndrome from 28 families. Antithyroglobulin antibodies were absent in all patients. Antimicrosomal and antithyroperoxidase antibodies were absent in all but one patient. Three patients with Alport's syndrome from the latter family were negative for antithyroid antibodies. In this large number of patients we found no association between Alport's syndrome and antithyroid antibodies. Screening for the presence of such antibodies in patients with Alport's syndrome is thus not warranted. The previously reported coexistence of the two disorders might be fortuitous.
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Lambert, M., Pirson, Y., De Nayer, P., & Van Ypersele de Strihou, C. (1992). No association between Alport’s syndrome and antithyroid antibodies. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 7(11), 1082-1084. https://hdl.handle.net/2078.5/131987 (Original work published 1992)