Identification of the gut microbial enzyme turning the urine yellow
(2024) Kidney International — Vol. 106, n° 2, p. 180-182 (2024)
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- (en) What did the study show? To identify the enzyme(s) responsible for the reduction of bilirubin to urobilinogen, the authors used a combination of experimental screening of common gut bacteria, with positive controls consisting of strains known to reduce bilirubin, comparative genomics analysis and biochemical inference, and validation through metabolomics. Hall et al. first used a fluorescence assay to screen extracts from bacterial gut strains grown in media with bilirubin, to identify bilirubin-reducing ...
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Harvent, M., & Devuyst, O. (2024). Identification of the gut microbial enzyme turning the urine yellow. Kidney International, 106(2), 180-182. https://doi.org/10.1016/j.kint.2024.03.018 (Original work published 2024)