Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?
(2007) Cancer Cell — Vol. 11, n° 5, p. 391-394 (2007)
Files
document.pdf
Restricted Access - Adobe PDF
- 412.84 KB
Details
- Authors
- Abstract
- Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene occurs in most colorectal cancers. The proto-oncogene c-MYC was one of the first genes linked to APC inactivation, but the in vivo significance of c-MYC's enhanced expression in intestinal cells with APC defects has been uncertain. Sansom et al. recently reported that targeted inactivation of c-Myc in murine intestinal epithelium potently inhibited phenotypical and transcriptional changes seen in Apc-deficient intestinal epithelium. While these findings are very interesting, some questions remain about the assignment of c-Myc as the pre-eminent beta-catenin-regulated gene in intestinal epithelium.
- Affiliations
Citations
Bommer, G., & Fearon, E. R. (2007). Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning? Cancer Cell, 11(5), 391-394. https://doi.org/10.1016/j.ccr.2007.04.015 (Original work published 2007)