Glucose inhibits glucagon secretion of mice with alpha cell specific deletion of KATP channels
(2023) 59th EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Germany) Hamburg (2.October.2023)
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- Authors
Gatineau, Eva 
- Abstract
- BACKGROUND AND AIMS: Glucose stimulates insulin and somatostatin (SST) secretion by closing β- and δ-cell KATP channels. By contrast, it inhibits glucagon release by largely unknown mechanisms. The role of α-cell KATP channels in the control of glucagon release and their implication in the glucagonostatic effect of glucose are hotly debated. They are particularly difficult to evaluate because α-, β- and δ-cells mutually influence their secretions. [...]
- Affiliations
Citations
Parambath, M., Lai, B. K., Chae, H.-Y., Gatineau, E., & Gilon, P. (2023). Glucose inhibits glucagon secretion of mice with alpha cell specific deletion of KATP channels. Diabetologia : clinical and experimental diabetes and metabolism, 66(Suppl 1), S44. https://hdl.handle.net/2078.5/249062 (Original work published 2023)