The use of pet-ct reduce mortality in patients with implant related infection associated staphyloccocus aureusbacteremia (sab)

Yildiz, Halil;Cornu, Olivier;D'Abadie, Philippe;Yombi, Jean Cyr
(2019) 38th Annual Meeting of the European Bone and Joint Infection Society (EBJIS) — Location: (Belgium) Antwerp (12.September.2019)

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(en) AIM: Staphylococcus aureus bacteremia (SAB) is associated with significant morbidity and mortality, 20-30 % risk of infection in patient with implant related infection (IRI) .18F-FDG PET/CT is helpfull in the management of SAB, leading to detection of more metastatic foci and treatment modification and finally decrease relapses and mortality rate (1). Our objective was to analyze mortality in high risk SAB patients undergoing 18F-FDG PET/CT and to see whether it’s use in patients with IRI reduced their mortality. METHOD: We performed a retrospective study at a university hospital in Belgium. All cases of high risk adult SAB between January 2014 and June 2017 were reviewed. We collected the clinical characteris¬tics including presence of metastatic foci on 18F-FDG PET/ CT, mortality at 1 year. RESULTS: A total of 102 patients were included. Twenty-one patient with IRI were identified (20.6%). In 94.1 % (N=96) SAB were due to methicillin-sensitive staphylococcus aureus (MSSA). 18F-FDG PET/ CT was performed in 47% (N =48) of patients and a metastatic foci was identified in 45.8% of cases (N=22/48). The detection of metastatic foci lead to surgical intervention in a site other than the site of IRI in 38% versus 14% (P < 0.001) in patients undergoing or not 18F-FDG PET/CT respectively. The overall mortality rate was 31.3 % (32/102). The mortality rate was 16.6% (8 /48) and 41.3 % (24/54) in patients undergoing or not 18F-FDG PET/ CT respectively (P=0.03). For IRI, the overall mortality was 9.3 % versus 15.6% in patients undergoing or not 18F-FDG PET/ CT respectively (P<0.001). There was a significant difference in mortality rate at 30 (P=0.001), 90 days (P=0.01) and one year (P=0.004) between patients undergoing or not 18F-FDG PET/ CT respectively. In bivariate analysis, the overall, 30, 90 days and one year mortality rate was significantly reduced among patient with kidney failure (P< 0.001), diabetic foot infection (P=0.006), age >70 years (P=0.007) and prosthetic joint or plate infection (P< 0.001) in whom the 18F-FDG PET/ CT was performed. CONCLUSIONS: Mortality rate was reduced in high risk SAB patients undergoing 18F-FDG PET/ CT. The use of 18F-FDG PET/CT reduced mortality in patients with PJI by detecting more metastatic site leading to more aggressive treatment.
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Yildiz, H., Cornu, O., D’Abadie, P., & Yombi, J. C. (2019). The use of pet-ct reduce mortality in patients with implant related infection associated staphyloccocus aureusbacteremia (sab). 38th Annual Meeting of the European Bone and Joint Infection Society (EBJIS), (Belgium) Antwerp. https://hdl.handle.net/2078.5/170854