The production of four top quarks ($\mathrm{t\bar{t}t\bar{t}}$) is studied with LHC proton-proton collision data samples collected by the CMS experiment at a center-of-mass energy of 13 TeV, and corresponding to integrated luminosities of up to 138 fb$^{-1}$. Events that have no leptons (all-hadronic), one lepton, or two opposite-sign leptons (where lepton refers only to prompt electrons or prompt muons) are considered. This is the first $\mathrm{t\bar{t}t\bar{t}}$ measurement that includes the all-hadronic final state. The observed significance of the $\mathrm{t\bar{t}t\bar{t}}$ signal in these final states of 3.9 standard deviations (1.5 expected) provides evidence for $\mathrm{t\bar{t}t\bar{t}}$ production, with a measured cross section of 36 $^{+12}_{-11}$ fb. Combined with earlier CMS results in other final states, the signal significance is 4.0 standard deviations (3.2 expected). The combination returns an observed cross section of 17 $\pm$ 4 (stat) $\pm$ 3 (syst) fb, which is consistent with the standard model prediction.
Benecke, A., Bruno, G., Bury, F., Caputo, C., David, P., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, S., Lemaitre, V., Mondal, K., Taliercio, A., Tran, T. T., Vischia, P., Wertz, S., CMS, Bethani, A., & et al. (2023). Evidence for four-top quark production in proton-proton collisions at $\sqrt{s}$ = 13 TeV. Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, 844. https://doi.org/10.1016/j.physletb.2023.138076 (Original work published 2023)