Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.

Garcia, Laetitia G;Lemaire, Sandrine;Kahl, Barbara C;Becker, Karsten;Van Bambeke, Françoise;et.al.
(2012) Journal of Antimicrobial Chemotherapy — Vol. 67, n° 12, p. 2873-2881 (2012)

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Authors
  • Garcia, Laetitia GUCLouvain
    Author
  • Lemaire, SandrineUCLouvain
    Author
  • Kahl, Barbara C
    Author
  • Becker, Karsten
    Author
  • Tulkens, Paul M.UCLouvain
    Author
  • Van Bambeke, Françoiseorcid-logoUCLouvain
    Author
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Abstract
Cooperation between acidic pH and oxidant species confers high potency to β-lactams against intracellular forms of menD SCVs of MRSA.
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Garcia, L. G., Lemaire, S., Kahl, B. C., Becker, K., Proctor, R. A., Tulkens, P. M., & Van Bambeke, F. (2012). Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species. Journal of Antimicrobial Chemotherapy, 67(12), 2873-2881. https://doi.org/10.1093/jac/dks325 (Original work published 2012)