Acute cerebral toxicity during concurrent anti-HER2 therapy and radiotherapy for breast cancer brain metastases
(2017) Belgian Journal of Medical Oncology — (2017)
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- Abstract
- Patients with HER2-positive advanced breast cancer frequently develop brain metastases. Dual anti-HER2 therapy significantly prolongs survival in previously untreated metastatic disease. However, no safety data exist on the concurrent use of pertuzumab, trastuzumab and brain radiotherapy. We describe two cases of previously untreated HER2-positive breast cancer and brain metastases, that developed acute cerebral toxicity during the concomitant administration of anti-HER2 therapy and whole-brain radiotherapy. Systematic clinical data is warranted to prove the safety of this association.
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Citations
van Marcke de Lummen, C. J., Duhoux, F., & Renard, L. (2017). Acute cerebral toxicity during concurrent anti-HER2 therapy and radiotherapy for breast cancer brain metastases. Belgian Journal of Medical Oncology. Accepted/in-press. https://hdl.handle.net/2078.5/176554 (Original work published 2017)