Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy

Ljungman, P.;Locasciulli, A.;De Soria, V.G.;Békássy, A.N.;Einsele, H.;et.al.
(2012) Bone Marrow Transplantation — Vol. 47, n° 9, p. 1217-1221 (2012)

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Authors
  • Ljungman, P.
    Author
  • Locasciulli, A.
    Author
  • De Soria, V.G.
    Author
  • Békássy, A.N.
    Author
  • Ferrant, AugustinUCLouvain
    Author
  • Einsele, H.
    Author
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Abstract
This prospective study was initiated in 1993 with the aim to study late effects and responses to antiviral therapy in a cohort of hepatitis C virus (HCV)-infected patients. A total of 195 patients were included from 12 centers. In all, 134 patients had undergone allogeneic and 61 autologous hematopoietic SCT (HSCT). The median follow-up from HSCT is currently 16.8 years and the maximum 27.2 years. Overall 33 of 195 patients have died of which 6 died from liver complications. The survival probability was 81.6% and the cumulative incidence for death in liver complications was 6.1% at 20 years after HSCT. The cumulative incidence of severe liver complications (death from liver failure, cirrhosis and liver transplantation) was 11.7% at 20 years after HSCT. In all, 85 patients have been treated with IFN; 42 in combination with ribavirin. The sustained response rate was 40%. The rates of severe side effects were comparable to other patient populations and no patient developed significant exacerbations of GVHD. Patients receiving antiviral therapy had a trend toward a decreased risk of severe liver complications (odds ratio0.33; P0.058). HCV infection is associated with morbidity and mortality in long-term survivors after HSCT. Antiviral therapy can be given safely and might reduce the risk for severe complications. © 2012 Macmillan Publishers Limited All rights reserved.
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Ljungman, P., Locasciulli, A., De Soria, V. G., Békássy, A. N., Brinch, L., Espigado, I., Ferrant, A., Franklin, I. M., O’Riordan, J., Rovira, M., Shaw, P., & Einsele, H. (2012). Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy. Bone Marrow Transplantation, 47(9), 1217-1221. https://doi.org/10.1038/bmt.2011.238 (Original work published 2012)