Comparison between pulmonary resistance and Penh in anaesthetised rats with tracheal diameter reduction and after carbachol inhalation.
(2005) Journal of Pharmacological and Toxicological Methods — Vol. 51, n° 2, p. 123-128 (2005)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- This study showed, by comparing Penh with R(L), that single-chambered plethysmography measuring Penh allows to detect carbachol-induced airflow limitation in spontaneously breathing, anaesthetised Sprague-Dawley rats, but poorly detects an increase in R(L) due to tracheal calibre reductions. These findings suggest that Penh might be only be used as an index of airflow limitation under well-defined experimental conditions.
- Affiliations
Citations
Kirschvink, N., Vincke, G., Onclinx, C., Peck, M. J., & Gustin, P. (2005). Comparison between pulmonary resistance and Penh in anaesthetised rats with tracheal diameter reduction and after carbachol inhalation. Journal of Pharmacological and Toxicological Methods, 51(2), 123-128. https://doi.org/10.1016/j.vascn.2004.10.002 (Original work published 2005)