Nmda Glutamatergic Receptors, Labeled With [h-3] Mk-801, in Brain Samples From Drug-free Depressed Suicides
(1993) Brain Research — Vol. 616, n° 1-2, p. 138-143 (1993)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 575.29 KB
Details
- Authors
- Abstract
- Glutamate receptors of the NMDA-subtype were quantitated by binding of [H-3]dizocilpine maleate (MK-801) in nine brain regions from 22 suicide victims (20-60 yr), with a firm retrospective diagnosis of depression, who had not recently received antidepressant drugs, and 20 age- and sex-matched controls. [H-3]MK-801-binding did not differ between suicides and controls in any region studied. Suicides who died violently did not differ from non-violent suicides and controls. A significative negative correlation was found between age and NMDA receptor-binding in the frontal cortex of suicide victims, but not in controls. This preliminary study provides little evidence for an important role of NMDA-binding sites in the pathophysiology of depression.
- Affiliations
Citations
Holemans, S., Depaermentier, F., Horton, RW., Crompton, MR., Katona, CLE., & Maloteaux, J.-M. (1993). Nmda Glutamatergic Receptors, Labeled With [h-3] Mk-801, in Brain Samples From Drug-free Depressed Suicides. Brain Research, 616(1-2), 138-143. https://doi.org/10.1016/0006-8993(93)90202-X (Original work published 1993)