Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter.

Haddam, Nahida;Samira, Sekkal;Dumont, Xavier;Taleb, Abdesselem;Bernard, Alfred;et.al.
(2009) Biomarkers — Vol. 14, n° 5, p. 292-298 (2009)

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Authors
  • Haddam, Nahida
    Author
  • Samira, Sekkal
    Author
  • Dumont, Xavier
    Author
  • Taleb, Abdesselem
    Author
  • Haufroid, Vincentorcid-logoUCLouvain
    Author
  • Lison, Dominiqueorcid-logoUCLouvain
    Author
  • Bernard, AlfredUCLouvain
    Author
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Abstract
Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO(2)) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO(2) and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO(2) interacted synergistically to decrease serum CC16 but not to increase serum SP-D. While further illustrating the potential of serum CC16 and SP-D, our study confirms that SO(2) can cause airways damage at exposure levels below current occupational exposure limits.
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Haddam, N., Samira, S., Dumont, X., Taleb, A., Haufroid, V., Lison, D., & Bernard, A. (2009). Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter. Biomarkers, 14(5), 292-298. https://doi.org/10.1080/13547500902989088 (Original work published 2009)