Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.
Block, S., Baccelli, C., Tinant, B., Van Meervelt, L., Rozenberg, R., Habib Jiwan, J.-L., Llabrès, G., De Pauw-Gillet, M.-C., & Quetin-Leclercq, J. (2004). Diterpenes from the leaves of Croton zambesicus. Phytochemistry, 65(8), 1165-1171. https://doi.org/10.1016/j.phytochem.2004.02.023 (Original work published 2004)