This study showed that after an inhalation challenge with an occupational allergen, the nasal mucosa displayed an imbalance in favor of TIMPs enzymes activity as compared to MMPs enzymes activity, represented in an increase in nasal levels of TIMP-2 during the course of the early reaction following the allergen challenge.
Castano, R., Miedinger, D., Maghni, K., Ghezzo, H., Trudeau, C., Castellanos, L., Wattiez, M., Vandenplas, O., & Malo, J.-L. (2012). Matrix metalloproteinases and tissue inhibitors of metalloproteinases in nasal lavage after an inhalation challenge with flour. The Laryngoscope, 122(4), 730-735. https://doi.org/10.1002/lary.23206 (Original work published 2012)