OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa.
(2011) Antimicrobial Agents and Chemotherapy — Vol. 55, n° 10, p. 4828-4833 (2011)
Files
ElGarchFetalAntimicrobAgentsChemother2011.pdf
Restricted Access - Adobe PDF
- 978.49 KB
Details
- Authors
- Abstract
- A carbapenem-resistant Pseudomonas aeruginosa strain (PA41437) susceptible to expanded-spectrum cephalosporins was recovered from several consecutive lower-respiratory-tract specimens of a patient who developed a ventilator-associated pneumonia while hospitalized in an intensive care unit. Cloning experiments identified OXA-198, a new class D β-lactamase which was weakly related (less than 45% amino acid identity) to other class D β-lactamases. Expression in Escherichia coli TOP10 and in P. aeruginosa PAO1 led to transformants that were resistant to ticarcillin and showed reduced susceptibility to carbapenems and cefepime. The bla(OXA-198) gene was harbored by a class 1 integron carried by a ca. 46-kb nontypeable plasmid. This study describes a novel class D β-lactamase involved in carbapenem resistance in P. aeruginosa.
- Affiliations
Citations
El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, G. (2011). OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(10), 4828-4833. https://doi.org/10.1128/AAC.00522-11 (Original work published 2011)