Small intestinal submucosa extracellular matrix (CorMatrix®) in cardiovascular surgery: a systematic review.
(2016) Interactive Cardiovascular and Thoracic Surgery — Vol. 22, n° 6, p. 839-850 (2016)
Files
MosalaNezhad-2016-Smallintestinalsubmucosaextracellular.pdf
Restricted Access - Adobe PDF
- 355.12 KB
Details
- Authors
- Abstract
- Extracellular matrix (ECM) derived from small intestinal submucosa (SIS) is widely used in clinical applications as a scaffold for tissue repair. Recently, CorMatrix® porcine SIS-ECM (CorMatrix Cardiovascular, Inc., Roswell, GA, USA) has gained popularity for 'next-generation' cardiovascular tissue engineering due to its ease of use, remodelling properties, lack of immunogenicity, absorbability and potential to promote native tissue growth. Here, we provide an overview of the biology of porcine SIS-ECM and systematically review the preclinical and clinical literature on its use in cardiovascular surgery. CorMatrix® has been used in a variety of cardiovascular surgical applications, and since it is the most widely used SIS-ECM, this material is the focus of this review. Since CorMatrix® is a relatively new product for cardiovascular surgery, some clinical and preclinical studies published lack systematic reporting of functional and pathological findings in sufficient numbers of subjects. There are also emerging reports to suggest that, contrary to expectations, an undesirable inflammatory response may occur in CorMatrix® implants in humans and longer-term outcomes at particular sites, such as the heart valves, may be suboptimal. Large-scale clinical studies are needed driven by robust protocols that aim to quantify the pathological process of tissue repair.
- Affiliations
Citations
Mosala Nezhad, Z., Poncelet, A., de Kerchove, L., Gianello, P., Fervaille, C., & El Khoury, G. (2016). Small intestinal submucosa extracellular matrix (CorMatrix®) in cardiovascular surgery: a systematic review. Interactive Cardiovascular and Thoracic Surgery, 22(6), 839-850. https://doi.org/10.1093/icvts/ivw020 (Original work published 2016)